Evaluation of the Anti-Ulcer Activity of Ethanolic Extract of Azadirachta indica Flower

The objective of present study is to evaluate the antiulcer activity of ethanolic extract of flower of Azadirachta indica. The cause of ulceration in patients is mainly due to hyper secretion of gastric acid and pepsin. Plant extracts and polyherbal formulations are some of the most attractive sources of new drugs and have been shown to produce promising results in the treatment of gastric ulcers. The antiulcer activity of ethanolic extract Azadirachta indica was investigated by pylorus ligation and indomethacin induced gastric ulcer in rats. The ethanolic extract of Azadirachta indica significantly reduced the ulcer produced by pylorus ligation. The ethanolic extract of Azadirachta indica at the dose of 200 and 400 mg/kg afforded 49.41% and 79.19% respectively, where as ranitidine 85.56 % against pylorus ligation induced ulcer. In Indomethacin induced gastric mucosal damage model, ethanolic extract of Azadirachta indica significantly reduced the incidence and severity of ulceration. The extract showed ulcer protection 50.81% and 75.97% in 200 mg/kg and 400 mg/kg doses respectively whereas the standard drug ranitidine exhibited 89.18% protection.